A Productive Expression Platform Derived from Host-Restricted Eilat Virus: Its Extensive Validation and Novel Strategy
Most alphaviruses are transmitted by mosquitoes and infect a wide range of insects and vertebrates.However, Eilat virus (EILV) is defective for infecting vertebrate cells at multiple levels of the viral life cycle.This host-restriction property renders EILV an attractive expression platform since it is not infectious for vertebrates and therefore p